Unfortunately, the AnkerMake M5 is currently not, to our knowledge, compatible with OctoPrint, Mainsail, Fluidd, or SimplyPrint. For the best 3D printing experience, consider other 3D printers that are compatible with this software.
Disclaimer: As of yet, it's not possible for us to support the Ankermake printer, due to the lack of OctoPrint or native Klipper support
SimplyPrint
No, AnkerMake M5 is not compatible with SimplyPrint